TGFβ/Smad3 signal pathway is not required for epidermal langerhans cell development
نویسندگان
چکیده
Ying-Ping Xu1,2,4,5, Yuling Shi1,2, Zhi-Zhong Cui4, Hong H. Jiang6, Li Li6, Xiao-Fan Wang7, Li Zhou1,2,3, and Qing-Sheng Mi1,2,3 1Henry Ford Immunology Program, Henry Ford Hospital, Detroit, MI 2Department of Dermatology, Henry Ford Hospital, Detroit, MI 3Department of Internal Medicine, Henry Ford Hospital, Detroit, MI 4Department of Preventive Veterinary Medicine, College of Animal Science and Veterinary Medicine, Shandong Agriculture University, Taian, China
منابع مشابه
TGF-β1-Smad signaling pathways are not required for epidermal LC homeostasis
Langerhans cells (LCs) are skin-homing dendritic cells (DCs) that have long been considered to be prototypic sentinel DCs due to their prominent position at the environmental barrier, and are essential for the induction of skin immunity and tolerance [1]. Transforming growth factor-β1 (TGF-β1) is a key factor in epidermal LC development and maintenance. The presence of TGF-β1 is a prerequisite ...
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